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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 47 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | LIS1 Rabbit Polyclonal Antibody detects endogenous levels of LIS1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LIS1 also known as PAFAH1B1 plays a critical role in neuronal migration during brain development, and proper function is essential for the formation of a normal cerebral cortex. Mutations in LIS1 can lead to lissencephaly, a condition characterized by a smooth brain surface and severe cognitive impairments. LIS1 is primarily localized in the cytoplasm and interacts with doublecortin, another protein implicated in neuronal migration. This interaction is vital for the regulation of microtubule dynamics, which are crucial for the movement of neurons to their appropriate locations in the developing brain. |
| Product Image Gallery | |
 Western blot analysis of extracts on KB, Hela, Mouse brain cells, using LIS1 Rabbit Polyclonal Antibody (EAB11171) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human brain tissue, sing LIS1 Rabbit Polyclonal Antibody (EAB11171) at 1:200 dilution.
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