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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 78 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Artemis (Ser516) Rabbit Polyclonal Antibody detects endogenous levels of Artemis protein only when phosphorylated at Ser516. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Artemis also known as DCLRE1C is a nuclear protein that is involved in V(D)J recombination and DNA repair. Artemis plays a crucial role in DNA damage response, specifically in repairing double-strand breaks, which are critical for maintaining genomic stability. Artemis interacts with DNA and other repair proteins, highlighting its importance in cellular processes that safeguard against mutations and cancer. Artemis functions as a single-strand-specific 5′ to 3′ exonuclease and forms a complex with DNA-dependent protein kinase (DNA-PKcs), which phosphorylates Artemis, enabling endonucleolytic activity on 5′ and 3′ overhangs and hairpins. These activities are vital for V(D)J recombination and DNA end processing during nonhomologous end joining, essential mechanisms for immune system development. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells treated with EGF, using Phospho-Artemis (Ser516) Rabbit Polyclonal Antibody (EAB11111) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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