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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 98 | Human, Mouse, Rat, Monkey |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-IRP1 (Ser711) Rabbit Polyclonal Antibody detects endogenous levels of IRP1 protein only when phosphorylated on Ser711. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IRP1 also known as IRP-1, ACO1 is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. IRP1 plays a crucial role in iron metabolism, which is vital for maintaining cellular homeostasis. IRP1 functions as a regulatory factor that modulates iron uptake and storage in response to cellular iron levels and stress signals. Specifically, IRP1 can bind to iron-responsive elements (IREs) in mRNA, thereby influencing the translation of proteins involved in iron transport and storage. This regulatory mechanism is essential because dysregulation of iron homeostasis can lead to various diseases, including anemia and neurodegenerative disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293 cells treated with Insulin, using Phospho-IRP1 (Ser711) Rabbit Polyclonal Antibody (EAB11107) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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