| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, FC, ELISA | 48 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:5000-20000 IHC-P=1:500-2000 IF/ICC=1:500-2000 FC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CtBP1 Mouse Monoclonal antibody detects endogenous levels of CtBP1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CtBP1 is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. CtBP1 is predominantly localized in the nucleus, where CtBP1 functions as a crucial transcriptional corepressor by interacting with various transcription factors and regulatory proteins to modulate gene expression. This localization is essential for its role in regulating processes such as embryonic development, cell differentiation, and cellular response to DNA damage, thereby maintaining cellular homeostasis and preventing oncogenic transformations. CtBP1 operates in concert with CtBP2 homolog and interacts with proteins like CtIP and BRCA1, highlighting CtBP1′s significance in complex regulatory networks involved in cancer biology and gene silencing. CtBP1′s ability to shuttle between nucleus and cytoplasm under specific cellular conditions underscores CtBP1′s dynamic role in cellular regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on HEK293, Jurkat, Raw264.7 cells, using CtBP1 Mouse Monoclonal antibody (EAB22521) at 1:10000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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