| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 43 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Cleaved-Caspase-4 (Gln81) Rabbit Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-4 protein resulting from cleavage adjacent to Gln81. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Caspase-4 is a member of the cysteine-aspartic acid protease (caspase) family. which are crucial for executing apoptosis, a programmed cell death process essential for maintaining cellular homeostasis and eliminating damaged cells. This family includes other well-known caspases such as caspase-1, caspase-3, and caspase-9, each playing distinct roles in apoptotic signaling pathways. Notably, caspase-4 is involved in inflammatory response and has been implicated in activating inflammatory caspases, which can lead to pro-inflammatory cytokine release. Proper functioning of caspase-4 is vital, as dysregulation can contribute to various diseases, including neurodegenerative disorders and cancer. |
| Product Image Gallery | |
 Western blot analysis of extracts on NIH/3T3 cells, using Cleaved-Caspase-4 (Gln81) Rabbit Polyclonal Antibody (EAB11005) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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