Other Biochemicals - MPTP hydrochloride

MPTP hydrochloride

Catalog #：EBC51160

Biological Activity

Synonyms

MPTP hydrochloride; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride; MPTP

Chemical Name

1-methyl-4-phenyl-3,6-dihydro-2H-pyridine;hydrochloride

Application

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is a Dopaminergic neurotoxin precursor of MPP+, widely used in research to study Parkinson′s disease

CAS Number

23007-85-4

Purity

≥98.0%

Molecular Weight

209.71

Molecular Formula

C12H16ClN

SMILES

Cl.CN1CCC(=CC1)C1=CC=CC=C1

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.7683 ml	23.8413 ml	47.6826 ml
5 mM	0.9537 ml	4.7683 ml	9.5365 ml
10 mM	0.4768 ml	2.3841 ml	4.7683 ml
50 mM	0.0954 ml	0.4768 ml	0.9537 ml

Solubility
DMSO: 18.0 mg/mL (85.8 mM) Ethanol: 40.0 mg/mL (190.7 mM) Water: 39.0 mg/mL (186.0 mM)

Product Description

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride (MPTP-HCl) is a dopaminergic neurotoxin that causes permanent symptoms of Parkinson′s disease by killing certain neurons in the substantia nigra of the brain. For this reason, it can be useful in the study of Parkinson′s disease. Specifically, it acts by targeting the mitochondria of neurons, where it is converted to 1-methyl-4-phenylpyridinium (MPP+). MPP+ is the active neurotoxin and inhibits mitochondrial complex I, leading to oxidative stress and neuronal death. In addition, MPTP-HCl affects dopamine metabolism and induces the release of glutamate. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is also known as MPTP hydrochloride and Dopaminergic neurotoxin.