| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IP, IHC-P, IF/ICC, ELISA | 133 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:20-200 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Jak1 (Tyr1034) Rabbit Polyclonal Antibody detects endogenous levels of Jak1 protein only when phosphorylated at Tyr1034. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
JAK1 also known as Janus kinase 1, JTK3 plays a crucial role in the signaling pathways of the immune system, particularly in the regulation of cellular functions downstream of activated cytokine receptors. JAK1 is primarily located in the cytoplasm, where JAK1 interacts with various cytokine receptors and transcription factors, facilitating the transmission of signals that lead to gene expression changes essential for immune responses. Proper localization of JAK1 is vital, as JAK1 ensures that the signaling cascade is initiated promptly upon cytokine binding, allowing for rapid cellular responses to immunological stimuli. Dysregulation of JAK1 activity can lead to impaired immune function or contribute to autoimmune diseases, making JAK1 a significant target for therapeutic intervention. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T, Raw264.7 cells, using Phospho-Jak1 (Tyr1034) Rabbit Polyclonal Antibody (EAB13011) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using Phospho-Jak1 (Tyr1034) Rabbit Polyclonal Antibody (EAB13011) at 1:100 dilution.
|
