Protein Inhibitors - Y-27632 dihydrochloride (CAS: 129830-38-2)

Y-27632 dihydrochloride (CAS: 129830-38-2)

Catalog #：EBC51165

Biological Activity

Synonyms

Y-27632 (hydrochloride); Y-27632; Y27632 HCl

Chemical Name

4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide

Application

Y-27632 dihydrochloride is a cell permeable inhibitor of ROCK-1 and ROCK-2 which plays an important role in Rho-mediated cell adhesion and smooth muscle contraction.

CAS Number

129830-38-2

Purity

≥99.0%

Molecular Weight

320.26

Molecular Formula

C₁₄H₂₃Cl₂N₃O

SMILES

C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

Target & IC50

ROCK-I: Ki = 140 nM

Shipping

Gel Pack

Storage

Store at 2-8°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.1225 ml	15.6123 ml	31.2246 ml
5 mM	0.6245 ml	3.1225 ml	6.2449 ml
10 mM	0.3123 ml	1.5612 ml	3.1225 ml
50 mM	0.0625 ml	0.3122 ml	0.6245 ml

Solubility
DMSO: 300.0 mg/mL (936.7 mM) Water: 100.0 mg/mL (312.2 mM)

Product Description

Y-27632 dihydrochloride is a selective Rho-kinase inhibitor. Y-27632 dihydrochloride suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.