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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P | 133 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Jak1 Mouse Monoclonal Antibody detects endogenous levels of Jak1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
JAK1 also known as Janus kinase 1, JTK3 plays a crucial role in the signaling pathways of the immune system, particularly in the regulation of cellular functions downstream of activated cytokine receptors. JAK1 is primarily located in the cytoplasm, where JAK1 interacts with various cytokine receptors and transcription factors, facilitating the transmission of signals that lead to gene expression changes essential for immune responses. Proper localization of JAK1 is vital, as JAK1 ensures that the signaling cascade is initiated promptly upon cytokine binding, allowing for rapid cellular responses to immunological stimuli. Dysregulation of JAK1 activity can lead to impaired immune function or contribute to autoimmune diseases, making JAK1 a significant target for therapeutic intervention. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, NIH/3T3, PC12 cells, using Jak1 Mouse Monoclonal Antibody (EAB11559) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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