| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IF/ICC, FC, ELISA | 60 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:2000-10000 IF/ICC=1:200-1000 FC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SLP-76 Mouse Monoclonal Antibody detects endogenous levels of SPL-76 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SLP-76 also known as LCP2 is an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. SLP-76 plays a pivotal role in T cell receptor signaling and is essential for the activation and development of lymphocytes, making SLP-76 a critical component in the immune response. Located primarily in the cytoplasm of T cells, SLP-76 interacts with various signaling molecules, including the adapter protein GRB2 and phospholipase C gamma 1 (PLC γ1), facilitating the transmission of signals that lead to T cell activation. The presence of multiple SH2/SH3-binding domains within SLP-76 allows SLP-76 to serve as a scaffold for assembling signaling complexes, which is vital for the propagation of signals that culminate in cellular responses such as cytokine production. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562, Molt-4, Jurkat cells, using SLP-76 Mouse Monoclonal Antibody (EAB22371) at 1:5000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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