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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 74 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | KCNQ1 Rabbit Polyclonal Antibody detects endogenous levels of KCNQ1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
KCNQ1 also known as KVLQT1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. KCNQ1 protein plays a crucial role in cardiac and auditory function as part of voltage-gated potassium channels essential for action potential repolarization in excitable cells. KCNQ1, in conjunction with β subunit KCNE1, is predominantly expressed in heart and cochlea, where KCNQ1 regulates slow, depolarization-activated potassium current. This regulation maintains electrical stability of cardiac cells and ensures proper hearing function. Mutations in KCNQ1 gene can lead to serious cardiac conditions, such as Long QT syndrome, by disrupting normal electrical signaling, while alterations in KCNQ4 are associated with hearing loss. |
| Product Image Gallery | |
 Western blot analysis of extracts on HT29, Mouse kidney cells, using KCNQ1 Rabbit Polyclonal Antibody (EAB14222) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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