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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 127 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | KCNH2 Rabbit Polyclonal Antibody detects endogenous levels of KCNH2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
KCNH2 also known as HERG is a voltage-activated potassium channel belonging to the eag family. KCNH2 plays a crucial role in cardiac repolarization. KCNH2 is a core determinant of the rapid delayed rectifier current that shapes cardiac action potential repolarization. Channel gating and surface expression integrate with membrane excitability programs and are modulated by signaling pathways that influence phosphorylation, trafficking, and proteostasis in excitable cells. Genetic and functional perturbation of KCNH2 is strongly associated with inherited and acquired long QT syndromes and arrhythmogenic susceptibility, making it a key node for studying electrophysiology, ion channel regulation, and cardiotoxicity mechanisms. |
| Product Image Gallery | |
 Western blot analysis of extracts on SH-SY5Y, MCF7 cells, using KCNH2 Rabbit Polyclonal Antibody (EAB14221) at 1:500 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 127 kDa; Observed band size: 148 kDa |
