| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 24 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TIMP1 Rabbit Polyclonal Antibody detects endogenous levels of TIMP1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TIMP1 plays a crucial role in regulating extracellular matrix remodeling by inhibiting metalloproteinases, which are enzymes responsible for degrading various components of the extracellular matrix. This function is particularly important in processes such as wound healing, tissue repair, and cancer progression, where maintaining balance between matrix degradation and synthesis is vital for tissue integrity. TIMP-1 interacts with other tissue inhibitors of metalloproteinases, including TIMP2, TIMP3, and TIMP4, which further underscores TIMP1′s significance in modulating metalloproteinase activity and influencing cellular behaviors. TIMP1 expression is regulated by various factors, including parathyroid hormone, highlighting TIMP1′s involvement in complex signaling pathways that govern cellular responses in different physiological and pathological contexts. |
| Product Image Gallery | |
 Western blot analysis of extracts on SH-SY5Y, HEK293 cells, using TIMP1 Rabbit Polyclonal Antibody (EAB14041) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human uterus tissue, using TIMP1 Rabbit Polyclonal Antibody (EAB14041) at 1:100 dilution.
|
