| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 127 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TERT Rabbit Monoclonal Antibody detects endogenous levels of TERT protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TERT also known as Telomerase, TRT is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. TERT plays a crucial role in maintaining telomere length by adding telomeric repeat sequences to the ends of chromosomes, which is vital for cellular longevity and stability. In most human somatic cells, telomerase activity is low or absent, leading to progressive telomere shortening with each cell division, a process associated with aging and cellular senescence. However, TERT is often reactivated in immortalized cells and various human tumors, contributing to unchecked proliferation. The interaction of TERT with telomerase RNA is essential for enzymatic function, and TERT mRNA expression levels correlate with telomerase activity across different cell lines, making TERT a significant marker in cancer research and potential therapeutic target. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562, Mouse lung cells, using TERT Rabbit Monoclonal Antibody (EAB22072) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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