| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC | 48 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SUV39H1 Rabbit Polyclonal Antibody detects endogenous levels of SUV39H1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SUV39H1, suppressor of variegation 3-9, selectively methylates Lysine 9 of the amino terminus of Histone H3 to generate a binding site for HP1 proteins. These HP1 proteins belong to a family of heterochromatic adaptor molecules that are implicated in both gene silencing and supra-nucleosomal chromatin structure. SUV39H1 contains both SET and chromo domains and is ubiquitously expressed. The enrichment of SUV39H1 at heterochromatic foci during interphase and centromere-specific localization during metaphase depends on the C-terminal SET domain. SUV39H1 is phosphorylated specifically at the G1/S cell cycle transition and, when forcibly expressed, suppresses cell growth. SUV39H1 acts as a long-range repressor that is capable of acting over several kilobases to silence basal promoters. |
| Product Image Gallery | |
 Western blot analysis of extracts on U87MG cells, using SUV39H1 Rabbit Polyclonal Antibody (EAB22162) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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