| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC | 57 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-200 IF/ICC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PTBP1 Rabbit Monoclonal Antibody detects endogenous levels of PTBP1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PTBP1 also known as hnRNP I is located on chromosome 19p13.3, and interaction with other hnRNP proteins, like hnRNP L, underscores importance in the spliceosome′s composition, which is vital for mRNA processing. hnRNP I plays a crucial role in regulating alternative splicing of pre-mRNAs, which is essential for generating protein diversity and regulating gene expression. hnRNP I is primarily localized in the nucleoplasm, where binding to the 3′ end of introns influences splicing mechanisms in normal cellular processes and translation of certain viruses, such as hepatitis C virus (HCV). hnRNP I′s ability to shuttle between the nucleus and cytoplasm further highlights significance in mRNA transport and translation, making this protein a key player in cellular function and viral pathogenesis. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562 cells, using PTBP1 Rabbit Monoclonal Antibody (EAB22044) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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