| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 58 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PSAP Rabbit Polyclonal Antibody detects endogenous levels of PSAP protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PSAP also known as Prosaposin is a member of the saposin family, which consists of four structurally related proteins—saposin A, B, C, and D—that are derived from the precursor protein prosaposin. PSAP plays a crucial role in lysosomal degradation of glycosphingolipids, acting as an essential cofactor for specific hydrolase enzymes. By modifying the lipid environment, PSAP enhances the accessibility of these enzymes to their substrates, thereby facilitating the breakdown of complex lipids. This function is particularly important in cellular metabolism and lipid homeostasis, as defects in PSAP have been linked to Gaucher′s disease, a genetic disorder characterized by glucocerebroside accumulation due to insufficient enzyme activity. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, NIH/3T3, Raw264.7 cells, using PSAP Rabbit Polyclonal Antibody (EAB13932) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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