| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 43 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PKA RI-α Rabbit Polyclonal Antibody detects endogenous levels of PKA RI-α protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PKA RI-α also known as PKA I alpha reg, Prkar1alpha, PRKAR1A is a tissue-specific regulator that downregulates the expression of several liver genes, which is vital for maintaining metabolic homeostasis and preventing aberrant cell growth. This regulatory function is particularly important in liver health, as dysregulation can lead to conditions such as hepatocellular carcinoma. PKA RI-α protein′s ability to modulate gene expression in response to cyclic AMP (cAMP) signaling highlights its significance in various physiological processes, including proliferation and metabolism. Notably, functional null mutations in the gene encoding PKA RI-α are linked to Carney complex, an autosomal dominant syndrome characterized by multiple neoplasms, including cardiac myxomas and endocrine tumors, underscoring PKA RI-α protein′s importance in tumor suppression and overall cellular regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562, NIH/3T3, HepG2, 293 cells, using PKA RI-α Rabbit Polyclonal Antibody (EAB13928) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using PKA RI-α Rabbit Polyclonal Antibody (EAB13928) at 1:200 dilution.
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