| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 17 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Cyclophilin A Rabbit Polyclonal Antibody detects endogenous levels of Cyclophilin A protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Cyclosporin A also known as PPIase A, CYPA, PPIA is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. Cyclosporin′s intracellular location allows interaction with various cellular components, including the immunosuppressant cyclosporin A (CsA), forming a trimolecular complex alongside calcineurin to inhibit calcineurin phosphatase activity. This inhibition is crucial for regulating T cell activation, making Cyclosporin a key player in immune responses. Additionally, Cyclosporin is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1), where Cyclosporin interacts directly with the capsid domain of the viral Gag polyprotein, facilitating efficient viral replication. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293, PC12, SH-SY5Y, Jurkat, HepG2, Mouse kidney cells, using Cyclophilin A Rabbit Polyclonal Antibody (EAB13925) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Mouse brain tissue, using Cyclophilin A Rabbit Polyclonal Antibody (EAB13925) at 1:100 dilution.
 Immunohistochemical analysis of paraffin-embedded Rat brain tissue, using Cyclophilin A Rabbit Polyclonal Antibody (EAB13925) at 1:100 dilution.
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