| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 66 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CRY1 Rabbit Polyclonal Antibody detects endogenous levels of CRY1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CRY1 is a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. CRY1 functions as a light-independent inhibitor of the circadian clock, interacting with key components such as Clock and BMAL1 to regulate gene expression involved in the light/dark cycle. Located primarily in the nucleus, CRY1 plays a vital role in the negative feedback loop that stabilizes circadian rhythms by forming heterodimers with other proteins like Per1 and Per2, which in turn inhibit Clock-BMAL1 dimer activity. This interaction is essential for proper functioning of the suprachiasmatic nucleus, the brain′s master clock, ensuring that physiological processes such as hormonal rhythms, sleep cycles, and feeding behaviors are synchronized with environmental light cues. |
| Product Image Gallery | |
 Western blot analysis of extracts on A549, Mouse liver cells, using CRY1 Rabbit Polyclonal Antibody (EAB13783) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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