| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 43 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CD46 Rabbit Polyclonal Antibody detects endogenous levels of CD46 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CD46 also known as MCP is a type I membrane protein and is a regulatory part of the complement system. CD46 plays a crucial role in regulating the complement system, which is essential for immune response and tissue homeostasis. CD46 functions by binding to complement components C3b and C4b, facilitating their degradation by serine protease factor I, thereby preventing damage to host tissues during immune responses. This regulatory mechanism is vital for maintaining self-tolerance and preventing autoimmune reactions. CD46 is expressed on a wide range of human cells, including thymocytes, T cells, B cells, monocytes, granulocytes, natural killer cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta, and sperm, but is absent on erythrocytes. |
| Product Image Gallery | |
 Western blot analysis of extracts on SW480 cells, using CD46 Rabbit Polyclonal Antibody (EAB13841) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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