| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 121 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CaSR Rabbit Polyclonal Antibody detects endogenous levels of CaSR protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CaSR is an integral membrane protein that plays a crucial role in calcium homeostasis by detecting and responding to changes in extracellular calcium levels. CaSR is primarily located in the parathyroid glands and kidneys, where CaSR functions as a sensor to regulate calcium concentration in the bloodstream. CaSR′s location is crucial for modulating parathyroid hormone secretion and renal calcium reabsorption, thereby maintaining calcium balance in the body. Mutations in CaSR can lead to significant disorders, such as autosomal dominant hypocalcemia and familial hypocalciuric hypercalcemia, highlighting CaSR′s critical role in calcium metabolism. CaSR is also expressed in other tissues, including the intestine, placenta, and brain, indicating CaSR′s diverse physiological functions. |
| Product Image Gallery | |
 Western blot analysis of extracts on LOVO cells, using CaSR Rabbit Polyclonal Antibody (EAB11634) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 121 kDa; Observed band size: 140 kDa |
