| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 384 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | BRCA2 Rabbit Polyclonal Antibody detects endogenous levels of BRCA2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
BRCA2 is located primarily in the nucleus, where BRCA2 facilitates the repair of DNA breaks, thereby preventing the accumulation of mutations that can lead to cancer. Nuclear localization of BRCA2 ensures ready availability to interact with other key players in the DNA repair process, such as Rad51. Mutations in the BRCA2 gene can lead to a loss of function, resulting in an increased risk of breast and ovarian cancers due to the inability to effectively repair DNA damage. BRCA2 contains multiple copies of a 70 amino acid motif known as the BRC motif, which is essential for interaction with Rad51, underscoring the intricate relationship between protein structure and function in cancer biology. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T cells, using BRCA2 Rabbit Polyclonal Antibody (EAB13404) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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