| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 51 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | LAP2/TMPO Rabbit Polyclonal Antibody detects endogenous levels of LAP2/TMPO protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LAP2 also known as thymopoietin, TMPO plays a crucial role in maintaining the structural integrity of the nuclear envelope, which is essential for proper cellular function. Located within the nuclear envelope, LAP2 interacts with chromatin and the nuclear lamina, contributing to the organization and stability of the nucleus. LAP2 features a unique amino-terminal domain that allows DNA binding, and contains the LAP2-emerin-MAN1 (LEM) motif, which is important for interactions with other nuclear proteins. Alternative splicing of LAP2 results in several isoforms, including LAP2α and LAP2β, which have distinct functions; LAP2α associates with the internal nucleoskeleton and binds to lamin A, while LAP2β interacts with lamin B and chromosomal barrier-to-autointegration factor (BAF), suggesting a role in chromatin stabilization. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, Mouse kidney cells, using LAP2/TMPO Rabbit Polyclonal Antibody (EAB13587) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 51 kDa; Observed band size: 51/75 kDa  Immunohistochemical analysis of paraffin-embedded Human liver tissue, using LAP2/TMPO Rabbit Polyclonal Antibody (EAB13587) at 1:200 dilution.
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