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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 90 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-MSK1 (Ser376) Rabbit Polyclonal Antibody detects endogenous levels of MSK1 only when phosphorylated at Ser376. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MSK1 also known as RLPK, RPS6KA5 is a key player in the mitogen-activated protein kinase (MAPK) signaling cascade, which is essential for various cellular processes, including cell growth, differentiation, and response to stress. MSK1 phosphorylates histone H3 and other substrates, thereby influencing gene expression and chromatin remodeling. This post-translational modification regulates transcriptional responses to extracellular signals, making MSK1 an important target for understanding cancer biology and other diseases linked to aberrant signaling pathways. MSK1 shares structural similarities with other ribosomal S6 kinase family members, which mediate cellular responses to growth factors and stress signals, highlighting MSK1′s importance in cellular homeostasis and signaling. |
| Product Image Gallery | |
 Western blot analysis of extracts on HuvEc cells treated with PMA, using Phospho-MSK1 (Ser376) Rabbit Polyclonal Antibody (EAB13427) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
 Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue, using Phospho-MSK1 (Ser376) Rabbit Polyclonal Antibody (EAB13427) at 1:100 dilution.
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