| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 139 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-SHIP2 (Tyr1135) Rabbit Polyclonal Antibody detects endogenous levels of SHIP2 when phosphorylated at Tyr1135. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SHIP2 also known as INPPL1 is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. SHIP2 plays a crucial role in cellular signaling pathways, particularly in the regulation of immune responses and cell growth. SHIP2 hydrolyzes phosphatidylinositol 3,4,5-trisphosphate (PtdIns P3) to phosphatidylinositol 3,4-bisphosphate (PtdIns P2), which is essential for inhibiting cell proliferation and promoting cell cycle arrest, particularly in glioblastoma cells. This function helps maintain cellular homeostasis and prevents uncontrolled cell growth, which can lead to tumorigenesis. SHIP2 is involved in the signaling pathways of various immune cells, including T and B lymphocytes, and SHIP2 expression is modulated by factors such as macrophage colony-stimulating factor (M-CSF) and epidermal growth factor (EGF). |
| Product Image Gallery | |
 Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using Phospho-SHIP2 (Tyr1135) Rabbit Polyclonal Antibody (EAB13348) at 1:200 dilution.
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