| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 56 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-TGF-β Receptor I (Ser165) Rabbit Polyclonal Antibody detects endogenous levels of TGFBR1 only when acetylated at Ser165. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TGF-β Receptor I also known as TGFβ RI, TGFBR1 is a 503 amino acid single-pass type I membrane protein, plays a crucial role in the TGFβ signaling pathway by forming a receptor complex with TGFβ RII, which is essential for mediating the growth-inhibitory effects of TGFβ. TGF-β Receptor I′s location in the cell membrane enables effective transduction of extracellular signals into the cell, influencing various cellular processes such as proliferation, differentiation, and apoptosis. Defects in the gene encoding TGF-β Receptor I have been linked to serious conditions such as aortic aneurysm familial thoracic type 5 and Loeys-Dietz syndrome, highlighting TGF-β Receptor I′s critical role in maintaining vascular integrity and normal developmental processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, Mouse liver cells, using Phospho-TGF-β Receptor I (Ser165) Rabbit Polyclonal Antibody (EAB13133) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
