| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 62 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | EAAT4 Rabbit Polyclonal Antibody detects endogenous levels of EAAT4 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
EAAT4 also known as SLC1A6 plays a crucial role in the central nervous system by functioning as an aspartate/glutamate transporter, predominantly expressed in the cerebellum. EAAT4 is essential for the reuptake of excitatory neurotransmitters L-glutamate and D-aspartate, which helps terminate the postsynaptic action of glutamate and prevents excitotoxicity—a condition that can lead to neuronal damage due to excessive accumulation of these neurotransmitters. The high affinity of EAAT4 for L-aspartate and L-glutamate underscores its importance in maintaining synaptic balance and protecting neurons from potential excitotoxic effects. Additionally, EAAT4′s transport activity is vital for proper cerebellar function, influencing motor coordination and cognitive processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on THP-1 cells, using EAAT4 Rabbit Polyclonal Antibody (EAB13024) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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