| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 46 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PEDF/SERPINF1 Rabbit Polyclonal Antibody detects endogenous levels of PEDF/SERPINF1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PEDF also known as SERPINF1 is a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. PEDF plays a crucial role in neuroprotection and differentiation, making PEDF vital for maintaining retinal health. PEDF inhibits angiogenesis and cell proliferation, which is particularly important in ocular diseases where abnormal blood vessel growth can lead to vision loss. Strategic localization of PEDF within the interphotoreceptor matrix allows effective influence on the underlying neural retina, thereby enhancing neuroprotective effects. PEDF induces neuronal differentiation and promotes central nervous system neuron survival, protecting against degeneration caused by serum withdrawal or glutamate toxicity, highlighting potential therapeutic implications in neurodegenerative conditions. |
| Product Image Gallery | |
 Western blot analysis of extracts on A431 cells, using PEDF/SERPINF1 Rabbit Polyclonal Antibody (EAB13022) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry analysis of paraffin-embedded Human prostate carcinoma tissue, using PEDF/SERPINF1 Rabbit Polyclonal Antibody (EAB13022) at 1:100 dilution.
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