| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 61 | Human, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Yes1 Rabbit Monoclonal Antibody detects endogenous levels of Yes1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Yes1 also known as Yes, c-Yes is a crucial member of the Src family of non-receptor tyrosine kinases. Yes1 play a significant role in various cellular processes, including cell proliferation, differentiation, motility, and adhesion. The c-Yes protein, encoded by the human c-Yes gene located on chromosome 18p11.31-p11.21, consists of 543 amino acids and shares over 80% homology with c-Src, particularly outside of their unique amino-terminal regions. This high degree of similarity allows c-Yes to participate in similar signaling pathways, but distinct SH3 and SH2 domains provide specificity in substrate binding, which is essential for cellular signaling. c-Yes modulates these pathways as a vital player in oncogenic processes, and understanding c-Yes interactions and regulatory mechanisms is crucial for developing targeted therapies in cancer treatment. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells, using Yes1 Rabbit Monoclonal Antibody (EAB22360) at 1:2000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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