| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2a | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 45 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:5000-20000 IHC-P=1:500-2000 IF/ICC=1:200-1000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TDP43 Mouse Monoclonal Antibody detects endogenous levels of TDP43 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TDP43 also known as TARDBP is a nuclear protein characterized by two RNA recognition motif (RRM) domains, which play a significant role in RNA processing and regulation. TDP43 is essential for binding to TAR DNA sequence motifs of HIV, functioning as a transcriptional repressor that inhibits HIV-1 transcription. TDP43 is involved in splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, highlighting TARDBP′s importance in maintaining proper cellular function. TDP43 is a major component of ubiquitin-positive inclusion bodies, which are associated with various neurodegenerative diseases, suggesting TDP43′s potential role in disease pathogenesis. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HEK293, SH-SY5Y, HepG2, PC12 cells, using TDP43 Mouse Monoclonal Antibody (EAB21987) at 1:10000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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