| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 60 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CD141/Thrombomodulin Rabbit Polyclonal Antibody detects endogenous levels of CD141/Thrombomodulin protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Thrombomodulin(TM) also known TRBM, CD141, THBD is a type I membrane receptor that is specific to endothelial cells. Thrombomodulin plays a crucial role in coagulation regulation. Thrombomodulin features a cysteine-rich extracellular domain with six EGF-like regions, which are essential for Thrombomodulin′s interaction with thrombin. This interaction activates protein C, leading to activated protein C (APC) generation, an important anticoagulant enzyme that, with protein S, inhibits coagulation by inactivating factors Va and VIIIa. TM′s significance in maintaining hemostatic balance is underscored by Thrombomodulin gene deletion resulting in embryonic lethality in mice, highlighting Thrombomodulin′s essential role in vascular biology and coagulation homeostasis. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562 cells, using CD141/Thrombomodulin Rabbit Polyclonal Antibody (EAB14936) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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