| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IF/ICC, ELISA | 56 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CYP26A1 Rabbit Polyclonal Antibody detects endogenous levels of CYP26A1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CYP26A1 also known as P450RAI1 is a member of the cytochrome P450 superfamily of enzymes. CYP26A1 is a crucial enzyme in retinoic acid catabolism, vital for regulating developmental processes and maintaining cellular homeostasis. By catalyzing retinoic acid hydroxylation, CYP26A1 helps modulate retinoic acid levels, preventing teratogenic effects during embryonic development. This regulation protects tailbud tissues from inappropriate retinoic acid levels, which can lead to severe developmental abnormalities. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor β2, highlighting intricate control mechanisms governing expression. Mutations in CYP26A1 have been linked to various congenital disorders, including caudal agenesis and spina bifida, underscoring significance in developmental biology. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HepG2 cells, using CYP26A1 Rabbit Polyclonal Antibody (EAB11844) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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