| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IF/ICC | 90 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:10-100 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | RRM1 Rabbit Monoclonal Antibody detects endogenous levels of RRM1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
RRM1 also known as R1 is a key component of the ribonucleotide reductase complex, catalyzes ribonucleotide conversion to deoxyribonucleotides for DNA synthesis. RRM1 plays a crucial role in the synthesis of deoxyribonucleotide triphosphates (dNTPs), the building blocks necessary for DNA replication and repair. The RRM1 subunit is notable for allosteric regulatory sites, which allow responses to cellular signals and modulate enzyme activity, thereby ensuring appropriate dNTP levels during the cell cycle. This regulation supports the fidelity of DNA synthesis and repair processes, vital for maintaining genomic stability. Additionally, ribonucleotide reductase participates in nucleotide excision repair, with both RRM1 and RRM2 subunits being induced in response to UV light, highlighting their role in cellular responses to DNA damage. |
| Product Image Gallery | |
 Western blot analysis of extracts on U2OS, 4T1, C6 cells, using RRM1 Rabbit Monoclonal Antibody (EAB22274) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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