| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IP, IHC-P, IF/ICC, ELISA | 45 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:5000-20000 IP=1:100-500 IHC-P=1:500-2000 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | RRM2 Mouse Monoclonal Antibody detects endogenous levels of RRM2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
RRM2 also known as R2 is a subunit of ribonucleotide reductase, an essential enzyme complex responsible for the synthesis and maintenance of deoxyribonucleoside triphosphates (dNTPs), which are vital for DNA replication and repair. RRM2 is localized in the cytoplasm and acts as the limiting factor for the catalytic activity of ribonucleotide reductase, with expression tightly correlated to the S-phase of the cell cycle. This regulation ensures a sufficient supply of dNTPs necessary for DNA synthesis, thereby maintaining genomic stability and enabling proper cell division. RRM2 interacts with the RRM1 subunit to form the active ribonucleotide reductase complex, facilitating efficient dNTP production during periods of rapid cell proliferation and in response to DNA damage. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562, HEK293, MCF7 cells, using RRM2 Mouse Monoclonal Antibody (EAB22289) at 1:10000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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