| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 53 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Presenilin 1 Rabbit Monoclonal Antibody detects endogenous levels of Presenilin 1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Presenilin 1 also known as S182, PSEN1 is located at the AD3 locus on chromosome 14q24.2. Presenilin 1 plays a critical role in processing amyloid precursor protein, which regulates amyloid-beta peptide production a key factor in Alzheimer′s disease pathogenesis. Mutations in the PSEN1 gene, which encodes Presenilin 1 have been linked to early-onset familial Alzheimer′s disease, highlighting Presenilin 1′s significance in neurodegenerative disorders. Presenilin 1 shares approximately 80% amino acid sequence identity with Presenilin 2, suggesting a conserved function within the seven-pass transmembrane receptor superfamily. Research continues to investigate whether Presenilin 1 and Presenilin 2 act as ligand-gated ion channels or G protein-coupled receptors, underscoring their potential importance in cellular signaling pathways. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Jurkat, C6 cells, using Presenilin 1 Rabbit Monoclonal Antibody (EAB21874) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
Predicted band size: 53 kDa; Observed band size: 22 kDa |
