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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 68 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Menin Rabbit Polyclonal Antibody detects endogenous levels of Menin protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Menin also known as MEN1, MEAI, SCG2 is a nuclear tumor suppressor that is mutated in patients with multiple endocrine neoplasia type I (MEN1). Menin plays a significant role in regulating gene transcription through covalent histone modifications, which are essential for cellular differentiation. Menin interacts with the TGFβ/Smad3 signaling pathway in osteoblasts, where Menin negatively regulates the transcriptional activities of BMP2/Smad1/5 and Runx2, thereby inhibiting late-stage differentiation. This regulatory function is vital for maintaining proper bone development and homeostasis. Menin influences the expression of insulin-like growth factor binding protein 2 (IGFBP-2) by modulating promoter activity, highlighting Menin′s role in growth factor signaling. Ectopic overexpression of Menin has been shown to induce apoptosis in murine embryonic fibroblasts in a Bax/Bak-dependent manner, further underscoring Menin′s importance in cellular regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on HuvEc, A549 cells, using Menin Rabbit Polyclonal Antibody (EAB11796) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry of paraffin-embedded Human tonsil tissue, using Menin Rabbit Polyclonal Antibody (EAB11796) at 1:200 dilution.
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