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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2a | Monoclonal | WB, ELISA | 58 | Human |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Lck Mouse Monoclonal Antibody detects endogenous levels of Lck protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LcK is a member of the Src family of protein tyrosine kinases (PTKs). Lck plays a crucial role in T cell signaling, particularly in the activation of T cell antigen receptors (TCRs). This activation is vital for the immune response, as it triggers downstream signaling pathways that lead to T cell proliferation, differentiation, and cytokine production. Lck protein is primarily localized in the plasma membrane of T cells, where it associates with the TCR complex, ensuring that it is positioned to effectively transmit signals upon receptor engagement. The human Lck gene is located on chromosome 1p35.1 and encodes a 509 amino acid protein, which is essential for the regulation of immune responses. |
| Product Image Gallery | |
 Western blot analysis of extracts on Molt-4, Jurkat cells, using Lck Mouse Monoclonal Antibody (EAB22057) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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