| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 82 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | γ-Catenin Mouse Monoclonal Antibody Antibody detects endogenous levels of γ-Catenin protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
γ-Catenin also known as Plakoglobin, JUP is a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions.γ-Catenin plays a crucial role in cellular adhesion by forming complexes with cadherins, particularly E-cadherin and N-cadherin. These complexes are essential for maintaining epithelial tissue integrity and facilitating intercellular communication. gamma-catenin in these complexes not only stabilizes cadherin-catenin interactions but also participates in signaling pathways that regulate cell proliferation and differentiation. Alterations in gamma-catenin expression or function have been implicated in various diseases, including cancer, where disrupted cell adhesion can lead to increased invasiveness and metastasis. |
| Product Image Gallery | |
 Western blot analysis of extracts on A431, MCF7, SKBR3 cells, using γ-Catenin Mouse Monoclonal Antibody (EAB21229) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human stomach cancer tissue, using γ-Catenin Mouse Monoclonal Antibody (EAB21229) at 1:200 dilution.
 Immunofluorescence analysis of U251 cell, using γ-Catenin Mouse Monoclonal Antibody (EAB21229)(green) at 1:200 dilution.
|
