| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, FC, ELISA | 86 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Glucocorticoid Receptor/GR Mouse Monoclonal Antibody detects endogenous levels of Glucocorticoid Receptor/GR protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GR (glucocorticoid receptor) also known as NR3C1 is a critical transcription factor that plays a vital role in mediating the physiological effects of glucocorticoids, which are steroid hormones involved in numerous biological processes such as metabolism, immune response, and stress regulation. GR is predominantly located in the cytoplasm, where GR exists in an inactive form bound to heat shock proteins, particularly HSP90. Upon binding to glucocorticoids, GR translocates to the nucleus, where GR regulates gene expression by either inducing or repressing target genes. This translocation allows GR to interact with specific DNA sequences and recruit co-regulators that modulate transcription. GR′s ability to influence gene expression is essential for maintaining homeostasis and responding to environmental changes, making GR a significant target for therapeutic interventions in conditions such as inflammation, autoimmune diseases, and cancer. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using Glucocorticoid Receptor/GR Mouse Monoclonal Antibody (EAB21967) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Predicted band size: 86 kDa; Observed band size: 94 kDa  Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue, using Glucocorticoid Receptor/GR Mouse Monoclonal Antibody (EAB21967) at 1:200 dilution.
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