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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 62 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Glypican-1 Rabbit Polyclonal Antibody detects endogenous levels of Glypican-1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Glypican-1 also known as GPC1 is a member of the glycosylphosphatidylinositol-anchored cell surface heparan sulfate proteoglycans, playing a significant role in cell adhesion, migration, and growth factor activity modulation. Glypican-1 interacts with fibroblast growth factors (FGFs), such as FGF-1, FGF-2, and FGF-7, which are essential for various cellular processes, including proliferation and differentiation. Glypican-1′s heparan sulfate chains facilitate binding to vascular endothelial growth factor 165 (VEGF165), acting as an extracellular chaperone that restores receptor binding ability after oxidative stress. This interaction supports hematopoietic stem and progenitor cell maintenance through Glypican-1 expression on marrow stromal cells. Glypican-1 shows elevated expression in human pancreatic cancer cells compared to normal pancreatic cells, suggesting involvement in tumor microenvironment and response to mitogenic stimuli like FGF-2. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using Glypican-1 Rabbit Polyclonal Antibody (EAB11767) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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