| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC | 71 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | FMRP/FMR1 Rabbit Monoclonal Antibody detects endogenous levels of FMRP/FMR1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
FMRP also known as FMR1 plays a crucial role in regulating synaptic plasticity and is essential for normal cognitive function. FMRP is primarily located in the cytoplasm, where FMRP associates with polyribosomes to facilitate the translation of specific mRNAs, thereby influencing protein synthesis in response to neuronal activity. This localization enables FMRP to modulate the translation of proteins involved in synaptic development and function, which is particularly important for learning and memory processes. In fragile X syndrome, FMRP gene undergoes transcriptional silencing due to the expansion of a CGG repeat in its 5′ untranslated region, leading to FMRP deficiency. FMRP absence disrupts normal synaptic function and contributes to cognitive impairments associated with the disorder. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562 cells, using FMRP/FMR1 Rabbit Monoclonal Antibody (EAB21952) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 71 kDa; Observed band size: 70-77 kDa |
