| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 45 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:2000-10000 IHC-P=1:100-500 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Cystathionine γ-Lyase/CTH Mouse Monoclonal antibody detects endogenous levels of Cystathionine γ-Lyase/CTH protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CTH(Cystathionine γ-lyase) also known as γ-cystathionase, CSE is a member of the trans-sulfuration enzyme family and participates in the trans-sulfuration pathway. CTH is a cytoplasmic enzyme produced in the cytosol and is responsible for catalyzing the pyridoxal phosphate-dependent β-disulfide elimination reaction resulting in ammonium, pyruvate and thiocysteine. The thiocysteine generated can subsequently react with other thiols, leading to the production of hydrogen sulfide (H2S), a signaling molecule that plays a vital role in various physiological processes. CTH expression in tissues such as the kidney, liver, vascular smooth muscle cells, and enterocytes underscores CTH′s importance in regulating cellular functions, including cell growth, modulation of neuronal excitability, and relaxation of smooth muscle cells. Furthermore, the endogenous production of H2S is essential for maintaining vascular homeostasis and influencing blood pressure regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HepG2, NIH/3T3, K562 cells, using Cystathionine γ-Lyase/CTH Mouse Monoclonal antibody (EAB21887) at 1:5000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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