| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 69 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | c-Rel Mouse Monoclonal Antibody detects endogenous levels of c-Rel protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
c-Rel also known as Rel is a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. c-Rel is a vital component of the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) signaling pathway, which is essential for regulating immune responses, cell proliferation, and survival. Through binding to specific κB sites in promoter regions of target genes, c-Rel plays a crucial role in transcriptional activation of immunoglobulin kappa light chain genes, thereby influencing B cell development and function. Proper regulation of c-Rel is important because dysregulation can lead to various immune disorders and contribute to cancer development. In contrast to v-Rel, which lacks a functional C-terminal transactivation domain and disrupts normal NFκB signaling, c-Rel maintains a role as a transcriptional activator, highlighting significance in maintaining cellular homeostasis and immune function. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Raji, Jurkat, HEK293, NIH/3T3 cells, using c-Rel Mouse Monoclonal Antibody (EAB21939) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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