| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, FC | 89 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 FC=1:10-100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CUL3 Rabbit Monoclonal Antibody detects endogenous levels of CUL3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CUL3 also known as Cullin3 is a member of the cullin protein family. CUL3 plays a crucial role in the ubiquitin-proteasome system, specifically in the selective degradation of proteins, which is vital for maintaining cellular homeostasis and regulating various biological processes, including cell cycle progression and signal transduction. CUL3 forms a part of the E3 ubiquitin ligase complex, where CUL3 associates with Nedd-8, enhancing activity and facilitating the ubiquitination of target substrates. CUL3′s ability to regulate protein degradation underscores its importance in cellular functions, as dysregulation can lead to various diseases, including cancer. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Mouse brain cells, using CUL3 Rabbit Monoclonal Antibody (EAB21910) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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