| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC | 72 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | ABCG2 Rabbit Monoclonal Antibody detects endogenous levels of ABCG2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ABCG2 also known as BCRP1, ABCP, MXR is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 plays a crucial role in transporting various substrates across cellular membranes using energy from ATP hydrolysis. ABCG2 confers resistance to several chemotherapeutic agents, including anthracyclines and topotecan, impacting treatment efficacy in cancer patients. ABCG2 is predominantly expressed in placenta, liver, intestine, and various stem cells, where ABCG2 regulates stem cell differentiation and maintains side population (SP) phenotype, indicating stem cell properties. ABCG2 undergoes post-translational modifications such as N-linked glycosylation, influencing stability and function, and dimerizes in vivo, highlighting a complex role in cellular processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on HL60, A549, HCT116 cells, using ABCG2 Rabbit Monoclonal Antibody (EAB21917) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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