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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P | 34 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-CDK2 (Tyr15) Rabbit Monoclonal Antibody detects endogenous levels of CDK2 only when phosphorylated at Tyr15. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CDK2 is a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. Cdk2 plays a fundamental role in cell cycle regulation by partnering with cyclins E and A to control the transition from the G1 phase to the S phase and the progression through the S phase, respectively. These interactions are critical for the initiation of DNA replication and the maintenance of genomic integrity, making Cdk2 essential for proper cell division and preventing uncontrolled cell proliferation. Dysregulation of Cdk2 activity is implicated in various cancers, highlighting Cdk2′s importance as a target for therapeutic intervention and cancer research. The ability of Cdk2 to form complexes with different cyclins allows for precise temporal control of kinase activity, ensuring that cells replicate DNA accurately and divide correctly. |
| Product Image Gallery | |
 Western blot analysis of extracts on NIH/3T3 cells, using Phospho-CDK2 (Tyr15) Rabbit Monoclonal Antibody (EAB21718) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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