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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 68 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-100 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TCF7L2/TCF4 Rabbit Monoclonal Antibody detects endogenous levels of TCF7L2/TCF4 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TCF7L2 also known as TCF4 is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 is primarily located in the cytoplasm, where TCF7L2 forms a complex with β-catenin before translocating to the nucleus to regulate the expression of Wnt target genes, many of which are associated with cancer. The interaction between TCF7L2 and β-catenin is essential for the activation of these genes, and the phosphorylation of TCF7L2 can influence TCF7L2′s interaction with other proteins, such as c-Jun, which is involved in the regulation of intestinal tumorigenesis. TCF7L2′s importance extends beyond cancer, as TCF7L2 has also been implicated in neuropsychiatric disorders, including bipolar affective disorder, highlighting TCF7L2′s significance in both developmental and pathological processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on SH-SY5Y, Jurkat, HepG2 cells, using TCF7L2/TCF4 Rabbit Monoclonal Antibody (EAB21651) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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