| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 83 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-RSK1 (Ser380) Rabbit Monoclonal Antibody detects endogenous levels of RSK1 protein only when phosphorylated at Ser380. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
RSK1 also known as MAPKAP kinase-1, RPS6KA1 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. RSK1 is a crucial serine/threonine kinase that serves as a key signaling intermediate in various cellular responses to ligand-activated receptor tyrosine kinases. One of the notable aspects of RSK1 is its unique structure, which features two non-identical complete kinase catalytic domains, allowing RSK1 to integrate multiple signaling pathways effectively. This structural complexity is essential for RSK1′s role in mediating cellular processes such as growth, differentiation, and survival, particularly in response to stress signals. RSK1 is predominantly expressed in tissues such as the brain and kidney, where RSK1 contributes to normal neuronal development and function. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, A431, NIH/3T3 cells, using Phospho-RSK1 (Ser380) Rabbit Monoclonal Antibody (EAB21601) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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