| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 33 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Caspase-6 Rabbit Monoclonal Antibody detects endogenous levels of Caspase-6 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Caspase-6 also known as MCH2, CASP6 is a member of the cysteine-aspartic acid protease (caspase) family of enzymes. which are crucial for the execution of apoptosis, a programmed cell death process essential for maintaining cellular homeostasis and development. Caspase-6 is primarily located in the cytoplasm and is activated in response to apoptotic signals, where caspase-6 plays a pivotal role in cleaving specific substrates that are vital for cellular integrity. Notably, caspase-6 has been shown to cleave nuclear lamins, which are integral to maintaining the structural integrity of the nuclear envelope and ensuring proper cellular morphology. The precise regulation of caspase-6 activity is critical, as dysregulation can lead to various pathological conditions, including neurodegenerative diseases and cancer. |
| Product Image Gallery | |
 Western blot analysis of extracts on HEK293, NIH/3T3, C6 cells, using Caspase-6 Rabbit Monoclonal Antibody (EAB21598) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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